Both ophthalmologists and dermatologists have different perceptions of the drug. Also, it causes contact lens intolerance and corneal ulcer on top. ![]() These adverse effects vary from mild reversible eye dryness to severe irreversible loss of night vision. This misuse increased the risk of developing adverse effects, especially on the ocular system. However, this misled the dermatologists into using isotretinoin for mild cases as well. The FDA approved isotretinoin for moderate and severe nodulo-cystic acne, in which it proved effective. This may justify the directed use of electrophysiological screening in professions that are night vision critical. One subject had subclinical changes remaining in the ERG 96 months after cessation of isotretinoin. Previous use of isotretinoin may have caused retinal toxicity in two subjects and laboratory evidence of night blindness in 11 further subjects. ![]() The group mean a:b ratio was 0.55 (0.04) compared to 0.69 (0.08) in the controls. The mean scotopic ERG b wave amplitude of the isotretinoin group was 496.5 microV (SD 51.3 microV) compared with 501.7 microV (62.3.1 microV) among the controls. 34 patients showed no abnormality in any parameters. To evaluate whether previous isotretinoin use induces permanent, measurable, and clinically significant abnormalities in night vision such that flying is precluded, and whether potential military and civilian commercial aviators should be screened routinely.Ī retrospective, non-interventional, consecutive case series of 47 individuals with a confirmed history of oral isotretinoin use were compared to 20 age and sex matched controls.Ĥ7 individuals (44 males and three females), age range 17-33, underwent Goldmann-Weekers dark adaptation (DA) and standard electroretinogram (ERG) according to ISCEV protocols.
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